This study was conducted to evaluate a repeated dose toxicity of urinary trypsin inhibitor (UTI) in Sprague-Dawley (SD) rats. UTI was administered to rats intravenous route at a dose level of high dose (300,000unit/kg/dya), medium dose
(30,000unit/kg/day) and low dose (3,000unit/kg/day) once a day for 4 weeks. Each groups were consisted of 10 male and female rats. There were no dose-related changes of clinical findings, body weights, food and water consumptions, opthalmoscopy,
organ
weights, urine analysis, biochemical examination and hematological findings in all the groups treated with UTI. Gross and histopathological findings revealed no evidence of specific toxicity related to UTI. Therefore, it was concluded that UTI
have
no
effect on repeated dose toxicity and side effect in SD rats.
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